NExtSEEK
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Overview

NExtSEEK is a layer built over FAIRDOM-SEEK for the active management of data from research projects that are still running. SEEK is built as a repository for finished work. NExtSEEK adds two things so you can use it while the work is going on:

  • Hard sample typing. Every sample belongs to a sample type, and each type has its own set of typed metadata fields.
  • Assays as edges. An assay is the link between two samples, not a box that holds them. Together the samples and assays form a network that follows the real experiment.

It was developed at the MIT BioMicro Center / Koch Institute Integrated Genomics and Bioinformatics Core Facility.

What it looks like

Two sample boxes joined by an arrow labelled experiment. The left box is a sample of one sample type, the right box a sample of another. The arrow is an assay, described by a protocol document.
A sample, an experiment (the assay) and a new sample. This is the whole model. See The data model.

Who uses it

NExtSEEK works best as a private instance that holds data before publication, so that a group or consortium can share data and metadata among its members. Today it manages data for these projects, plus independent project work:

Project Link
HI-IMPAcTB NIAID program page
MIT Superfund Research Program (SRP) superfund.mit.edu
Metastasis Network of Cancer (MetNet) NIH RePORTER
Cancer Systems Biology Consortium (CSBC) NCI program page
Break Through Cancer (BTC) breakthroughcancer.org
CRG-Griffith

Each project has a project page with its overview, a sample flow graph and templates. See Projects and templates. For how many samples each project holds, see Statistics.

Where published data goes

When a study is published, its data and metadata are deposited in FAIRDOMHub, the public repository run by the SEEK team. The public studies of these projects are listed under the Published Studies link in the sidebar.

Where to start

You want to Read
Get an account and find your way around Using NExtSEEK
Understand samples, sample types and assays The data model
Add samples, data files or protocols Uploading
Find and download data Searching and downloading
Ask questions in plain language Nessie, the assistant

If you want to run your own NExtSEEK instance, see Installation.

Cite NExtSEEK

Pradhan D, Ding H, Zhu J, Engelward BP, Levine SS. NExtSEEK: Extending SEEK for Active Management of Interoperable Metadata. J Biomol Tech 2022;33(1). https://doi.org/10.7171/3fc1f5fe.db404124